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HIGH GT EXPRESSION AND INTRATUMOR DRUG ACTIVATION The high expression of GT within aggressive and drug-resistant tumors implies that GSH-conjugated prodrugs, activated at the cell surface by GT, should be particularly effective against GT-positive tumors

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Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3 enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors

Informal reports cannot show whether 5-Amino-1MQ caused a change, and animal timelines should not be converted into human expectations

P., Muchowski, P