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GSSG is the main source of oxidizing equivalents to provide the adequate environment necessary for favoring disulfide bond formation and proper folding of nascent proteins

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172,173 Furthermore, berberine enhanced the expression of tight junction proteins such as occludin and claudin-1, highlighting its combined microbiota- and barrier-restoring function

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It helps reduce irritated and blotchiness, contributing to a clearer and more uniform complexion

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