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One of the earliest pieces of evidence of the association between thiols and skin came from the effect of an extract of human skin that contained an active sulfhydryl-containing compound

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Chronic stimulation of this system by dietary exorphins has been proposed to contribute to symptoms such as irritability, antisocial behaviors, and apathyclinical features observed in a subset of individuals with T21which may underlie behavioral patterns resembling those seen in autism spectrum disorder [81]

NHLBIPatricia Noel, Robert Smith