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doi: 10.3390/ijms22157765
Hepatic PGC-1 overexpression exacerbates APAP-induced hepatotoxicity and mortality in mice Since Pgc-1 is one of the master regulators of liver metabolism and given its increased expression observed when mice were challenged with HFD, we decide to decipher whether PGC-1 induction could contribute to the worsening of APAP-induced hepatotoxicity
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In a randomized controlled trial comparing the effect of aromatase inhibitor and GnRH agonist on UF, it was found that both interventions are able to reduce the myoma volume and symptoms
Starting with lower doses and monitoring for adverse effects is a standard, cautious approach before adjusting upward based on clinical response
The possible interaction of SERMs with endogenous estrogen and signaling pathways will also need to be investigated, as the interplay between exogenous SERMs and endogenous estrogen levels needs to be carefully considered to ensure optimal therapeutic effects
