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Key sources included the US Food & Drug Administration (FDA), European Food Safety Authority (EFSA), National Institutes of Health (NIH) Office of Dietary Supplements, National Center for Biotechnology Information (NCBI/PubMed), US Department of Agriculture (USDA) Agricultural Research Service, World Health Organization (WHO) Global Health Observatory, Organisation for Economic Co-operation and Development (OECD) Health Statistics, EU Eurostat Health Database, National Center for Health Statistics (NCHS/CDC), International Food Information Council (IFIC), Council for Responsible Nutrition (CRN), Natural Products Association (NPA), United States Pharmacopeia (USP), International Nomenclature of Cosmetic Ingredients (INCI), Personal Care Products Council (PCPC), Codex Alimentarius Commission, European Medicines Agency (EMA), Japan Ministry of Health, Labour and Welfare (MHLW), China National Health Commission (NHC), Health Canada, Therapeutic Goods Administration (TGA) Australia, and national health ministry reports from key markets

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No published case reports document this outcome with KLOW specifically, but the mechanism is well-established with native Klotho overexpression in transgenic models

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