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Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

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While these findings are encouraging, its important for our patients to understand that robust human clinical trials are still lacking

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ELISA assay for DNA fragmentation DNA fragmentation was quantified using a commercially available ELISA kit from Roche (Indianapolis, IN) in accordance with the manufacturers instructions