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36-38 CURRENT GUIDELINE RECOMMENDATIONS: ROLES OF INCRETIN-BASED THERAPIES AND SGLT-2 INHIBITORS The use of currently available treatments for T2DM are guided by clinical recommendations from several organizations, including the ADA and the AACE/ACE
385,387 PF1801 displays its anti-inflammatory effects by lowering levels of inflammatory mediators such as TNF, IL-6, and HMGB1, and enhances the cells antioxidant capability by upregulating molecules like Nfe2l2, Hmox1, Gclm, and Nqo1, which further improves cellular defense against oxidative stress and protects them from further damage
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