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MTHFR gene mutations and loss of function MTHFR C677T Heterozygous = 40% loss of function MTHFR C677T Homozygous = 70% loss of function MTHFR A1298C Heterozygous = (loss of function research not known) MTHFR A1298C Homozygous = between 50-70% MTHFR C677T & MTHFR A1298C heterozygous = compound heterozygous = 50% loss of function MTHFR gene mutation treatment may involve supplementation for deficiencies and specific medications to manage diseases caused by the MTHFR mutation
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