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46 In keeping with this, transgenic mice overexpressing GIP exhibit increased bone mass and enhanced osteoblast activity at 24 months of age, whilst GIPR KO leads to decreased BMD, cortical thickness, and overall bone strength
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Protective exercise responses in the dentate gyrus of Alzheimers disease mouse model revealed with single-nucleus RNA-sequencing
Its also unique in targeting both GLP-1 and GIP receptors rather than GLP-1 alone
However, in the CV safety outcome trials, a numerical imbalance in adjudicated cases of acute pancreatitis was noted (124127, 129, 130), although the absolute risk was still very low
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