Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application
Clinical Efficacy: Research published in The Journal of Clinical and Aesthetic Dermatology demonstrated significant improvements in melasma lesions when patients combined oral PLE with sunscreen
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Shameli K, Ahmad MB, Jaffar Al-Mulla EA, Ibrahim NA, Shabanzadeh P, Rustaiyan A, Abdollahi Y, Bagheri S, Sanaz A, Sani UM, Zidan M: Green biosynthesis of silver nanoparticles using Callicarpa maingayi stem bark extraction
& Ward, M
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