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The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role

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Currently, keloids are considered a chronic inflammatory disease with cancer-like tendencies

Future research directions in this field are likely to focus on several aspects

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