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GLP-1 agonists produce larger absolute weight reductions (1520% over 68 weeks in clinical trials), but the MOTS-c stack may preserve lean mass more effectively due to AMPKs role in muscle glucose uptake and mitochondrial biogenesis
References Ohno T, et al
Understanding how reconstitution differs between these peptides prevents the most common calculation errors researchers make when transitioning protocols
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That approval does not extend to general fat-loss use, off-label protocols, or any use outside the approved patient population and clinical oversight
