The first GLP-1RA was approved by the FDA (U.S
Hospitalization: In severe cases, hospitalization may be required for the restoration and maintenance of hydration, to control pain and vomiting, and possibly the administration of antibiotics
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Nassar M, Nassar O, Abosheaishaa H, Misra A
The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) (20)
A dual-targeted molecule for disease-activatable proteolysis targeting chimeras and targeted radionuclide therapy of cancer