Neuronale Zeroidlipofuszinose 12 (NCL-12) Einzelanalyse It is characterized by degeneration

It is characterized by degeneration of the cerebellar structures

Clinical signs are non-specific and include abdominal pain

First clinical symptoms usually appear at 1 or 2 years of age

This phenotype is called agouti (wolf grey or wolf sable)

The colour of eumelanin stripes is defined by B and D-Loci

Neuronale Zeroidlipofuszinose 12 (NCL-12) Einzelanalyse It is characterized by degenerationNeuronal ceroid lipofuscinoses (NCLs) are a group of heritable diseases characterized by progressive neuronal degeneration and accumulation of autofluorescent cytoplasmic inclusions in the brain, retina and other tissues. Clinical symptoms and progress of the disease include increased rates of irritability, with the possibility of outbursts of aggression, hallucinations, hyperactivity and seizures. Most animals lose their ability to coordinate