D-Lokus (d2) Startseite Genotyp / Risiko

Genotyp / Risiko

Dog is homozygous for normal allele

wird sich jedoch im Laufe der Zeit verschlechtern und das detaillierte Sehen wird verloren gehen

severe self-mutilations of the feet including claw loss

Mutation: MYH9 gene

D-Lokus (d2) Startseite Genotyp / RisikoD Locus is responsible for coat colour dilution. Known mutations of the MLPH gene (melanophilin) are responsible for most cases of diluted colours. MLPH gene encodes a protein melanophilin, a key component in the hair and skin pigment formation. A mutation in the gene causes the improper distribution of melanosomes and coat colour dilution. It has an effect on the formation of black eumelanin as well as red yellow pheomelanin, though in lesser extent.