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The affected puppies often have to be euthanised due to severe symptoms and the risk of a sudden death
ein rezessives Allel kann an die Nachkommen weitergegeben werden
The disease is neither progressive nor life-threatening
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life-threatening disorder of weak and thin heart
Zentronukleäre Myopathie (IMGD) - Deutsche Dogge Mischling The affected puppies often haveCharacteristic signs of centronuclear myopathies include generalized muscle weakness, atrophy, predominance of type I fibres, and aberrant cell positioning of nuclei and mitochondria. In Great Danes generalized muscle atrophy, exercise intolerance, exercise induced tremor and muscle wasting characterize the disease. The disease typically starts before 10 months of age, is highly progressive, and most of the affected dogs are euthanized before 18
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