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The enzyme succinic semialdehyde dehydrogenase has important role in part of the metabolism of the neurotransmitter GABA
Die Kombination von zwei rezessiven Allelen führt zu schokoladen-/leberbrauner Farbe (zum Beispiel zwei bc-Allele oder ein bc- und ein bs-Allele)
Affected dogs also tend to suffer increased dental disease
the breed standard allows only one coat length (long or short variant is unacceptable)
Mutation: SLC7A9 gene
Progressive Retinaatrophie (PRA-CNGA1) option-set-443684-checkbox-1 The enzyme succinic semialdehyde dehydrogenaseProgressive retinal atrophy (PRA) is an inherited disease that occurs in many breeds of dogs and is reflected in various clinically indistinguishable forms. Progressive rod and cone degeneration in retina leads to progressive vision loss, which can end with total blindness. A form of PRA called CNGA1 PRA was described in Shetland sheepdog. On average clinical signs become apparent at 5 years of age (2 11 years). The breed suffers from an additional
