Lethale Akrodermatitis (LAD) All Congenital hypothyroidism in this breed

Congenital hypothyroidism in this breed is often presented with goiter - a swelling in the neck resulting from an enlarged thyroid gland

The amount and distribution of pheomelanin may vary between individual dogs and between breeds

because it arose in Collie breed and affected dogs have hypopigmented coats

Inheritance: autosomal dominant (incomplete penetrance)

The disease was first identified in Shetland sheepdogs

Lethale Akrodermatitis (LAD) All Congenital hypothyroidism in this breedLethal acrodermatitis (LAD) is characterized by poor growth, immune deficiency, and skin lesions, especially at the paws. Affected puppies show characteristic skin lesions on the feet and on the face, diarrhoea, bronchopneumonia, and a failure to thrive. Coat color can be diluted in pigmented skin areas. LAD affected dogs are immunodeficient and frequently suffer from skin infections with Malassezia or Candida. They grow slower than their non affected