B-Lokus (Lancashire Heeler) Hunde Hereditary nasal parakeratosis (HNPK) is

Hereditary nasal parakeratosis (HNPK) is an inherited autosomal recessive skin disorder

Other clinical symptoms include changes in barking

Eine Mutation in diesem Gen ist verantwortlich für das Auftreten einer demyelinisierenden peripheren Neuropathie mit abnormal gefaltetem Myelin

mask is not expressed

with further clinical signs evident in early life

B-Lokus (Lancashire Heeler) Hunde Hereditary nasal parakeratosis (HNPK) isGene TYRP1 (Tyrosinase related protein 1) is responsible for chocolate liver brown colour in dogs. This coat colour is inherited recessively. There are 4 different variants on B Locus in Lancashire Heeler: bc, bs, bd and be. Combination of any two recessive alleles will result in chocolate liver brown colour (for example two bc alleles or one bc and one bs allele). Because TYRP1 gene is related to eumelanin production, it only affects dogs which have