E-Lokus DogCheck Dilated Cardiomyopathy (DCM) is an

Dilated Cardiomyopathy (DCM) is an inherited hereditary disease that occurs in dogs

um das Vorhandensein von rezessiven Allelen (bc

In Australian Shepherds the disease was identified between 4 and 19 months of age

Mutations in this gene can lead to impaired hunger regulation and obesity

was zu einer Verschlechterung der Innenohrhaare und Taubheit führt

E-Lokus DogCheck Dilated Cardiomyopathy (DCM) is anMelanocortin 1 receptor (MC1R) on E Locus is responsible for regulation of pigment production in melanocytes. Mutation inMC1R gene results in non functional receptor and switches pigment production to pheomelanin. Because production of eumelanin is disabled, effect of other loci is not possible. Mutation is recessive therefore, two such alleles are necessary for yellow red (pheomelanin) coat colour expression. Different dog breeds with genotype e e